top of page
lipid nanoparticle, lipid nanoparticles, Lipid NP,  LNP, LNP preparation, LNP formulation, lipid nanoparticle synthesis, liposome, mRNA encapsulation,   precigenome, mRNA LNP, PLGA, drug delivery, precision medicine, nanogenerator, flex-s, flex-m, pro, max, precisionnanosystems, pni, NanoAssemblr, ignite, spark

液滴生成系统with 微流控液滴发生器芯片

droplet generation, droplet generator, microhigh_speed_imaging_flow_controller, droplet generation, droplet generator, microfluidic droplet, droplet generation chip, droplet generator chip, microfluidic pump, microfluidic pressure pump,  microfluidic pressure controller, microfluidic,  high-speed imaging
微粒,尤其是聚合物微粒,以其优异的性能在药物输送、生物传感等制药工业等各个领域显示出巨大的生物医学应用潜力。
 
通过微流控技术合成微粒比传统的批量合成工艺具有优势,因为它能够在尺寸和形状上具有更好的均匀性。例如,在药物输送领域,纳米粒子可以由嵌段共聚物合成,例如 PLGA,这是最常用的生物可降解材料,用于输送亲水性和疏水性化合物。 

粒子合成原理:

PreciGenome 液滴生成系统广泛用于微粒合成。它采用微流体装置来控制和调节聚合物颗粒的生产。下面的示意图说明了为粒子合成而设计的具有聚焦流几何结构结的设备。 
DG Schematic.png

微粒合成:

扩大的连接处的示意图,孔口处受控的破碎液滴。通过孔口的流动能够控制液滴破碎,这是产生单分散微乳液所必需的

 系统优势:​

High Performance & Efficiency
  • Tunable size 
  • Low PDI
  • High encapsulation efficiency
Total Solution
Cost Effective
  • Affordable configurations

  • Cost effective solutions

  • Open platform 

Custom Design & Service
  • Research collaboration

  • Custom design

  • OEM & Contract manufacturing

high_speed_imaging_flow_controller, microparticle system, nanoparticle synthesis, microfluidic mixing, high-speed imaging,drug delivery, PLGA synthesis, lipid synthesis, liposome synthesis

微流控方法的优点:

The iFlow system offers a variety of  numerous benefits by using microfluidic systems to produce PLGA mircoparticles for drug delivery applications, such as:

  • Enhanced control of particle fabrication process over each phase

  • High yields

  • Easy scale-up

In drug delivery, precise particle production is essential for controlled and sustained release of drugs using biodegradable polymers. The iFlow systems offer advantages like enhanced control over particle production, higher yields, and easy scale-up. Targeted drug delivery is also possible by functionalizing particle surfaces or using the EPR effect. The release profiles of the polymer-drug matrix can be adjusted by varying factors like microparticle size, polymer molecular weight, lactide to glycolide ratio, and drug concentration.

相关应用说明:

PG_SYN_1.png

PLGA Nanoparticle Synthesis

Drug-loaded PLGA nanoparticles (NPs) can be synthesized by our system. PLGA NPs synthesis in continuous flow microfluidics by the nanoprecipitation process.

Use case 3.gif

Liposome Nanoparticle Synthesis

Precise lipid and liposome synthesis by microfluidic mixing methods. Efficient method for generating nanoparticles for targeted drug or nutrient delivery

microparticles_droplet.JPG

PLGA Droplet-based Microparticle Synthesis

PLGA Microparticles are produced via template droplets that turn into microparticles by solvent evaporation. Easy to generate PLGA droplets. 

Read More
Inquiry
bottom of page