LipidFlex™ 脂质纳米颗粒和脂质体制剂
LipidFlex™ 是一种三组分脂质混合物。
LipidFlex™ 可直接用于生成用于小分子封装的脂质体。除了不同的阳离子/可电离脂质，LipidFlex™ 还可用于生成脂质纳米颗粒 (LNP)，用于封装小分子和核酸，如 mRNA、DNA、蛋白质等。
LipidFlex™ Pack 套件包括 LipidFlex 和可电离脂质 (SM102)
Benefits of RNA-LNP Products
Enhanced delivery
Facilitate more efficient uptake of RNA by cells, leading to higher levels of protein expression.
High encapsulation efficiency
Encapsulation Efficiency (E.E.%): >80% (>95-99% w. optimized conditions)
Reduced immunogenicity
Improve the safety and efficacy of RNA-based therapies and vaccines.
High stability
Protect RNA from degradation by enzymes and other factors, allowing for improved delivery of the RNA to the target cells.
实验数据：
GFP expression in K562 (left) and HepG2 (right) cell lines after48 hours treated by eGFP mRNA-LNP
Accelerate your LNP Formulation Development
In Vitro
Evaluation
Quickly screen LNP formulations for cellular uptake and viability
In Vivo
Distribution
Understand the localization of your payloads complex
Scale-up and Optimization
Leverage insights & our expertise to refine LNP formulations for scale-up studies
特征：
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In vitro or in vivo expression and distribution
Evaluate delivery of mRNA ( eGFP, FLuc, mCherry, etc.) for in vitro transfection
Evaluate LNP uptake with conveniently labeled lipophilic dyes
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Analytical or process development
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Experimental control reference
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