LipidFlex™ Premade Lipid Nanoparticles
Lipid nanoparticles (LNPs) are nanoscale particles composed of lipids, serving as efficient delivery vehicles for various drugs. These drugs include mRNA, circular RNA, self-amplifying RNA, siRNA, protein, small molecule, etc. LNPs are the most popular methods for RNA delivery. It offer a variety of benefits, including high stability, high delivery efficiency, reduced immunogenicity, and specific targeting delivery. With such strengths, LNPs hold great promise for developing safe and effective RNA-based treatments and vaccines.
PreciGenome offers premade LNPs to quickly assess nucleic acid cargo delivery, viability, and uptake. These ready-to-use LNPs are encapsulated mRNA & circular RNA with high quality and in vitro & in vivo activity. It can be used as the control of your RNA experiment for both in vitro & in vivo applications, or to assess the efficiency of LNP-based RNA delivery systems.
Benefits of RNA-LNP Products
Enhanced delivery
Facilitate more efficient uptake of RNA by cells, leading to higher levels of protein expression.
High encapsulation efficiency
Encapsulation Efficiency (E.E.%): >80% (>95-99% w. optimized conditions)
Reduced immunogenicity
Improve the safety and efficacy of RNA-based therapies and vaccines.
High stability
Protect RNA from degradation by enzymes and other factors, allowing for improved delivery of the RNA to the target cells.
Experiment data
GFP expression in K562 (left) and HepG2 (right) cell lines after48 hours treated by eGFP mRNA-LNP
Accelerate your LNP Formulation Development
In Vitro
Evaluation
Quickly screen LNP formulations for cellular uptake and viability
In Vivo
Distribution
Understand the localization of your payloads complex
Scale-up and Optimization
Leverage insights & our expertise to refine LNP formulations for scale-up studies
Applications
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In vitro or in vivo expression and distribution
Evaluate delivery of mRNA ( eGFP, FLuc, mCherry, etc.) for in vitro transfection
Evaluate LNP uptake with conveniently labeled lipophilic dyes
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Analytical or process development
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Experimental control reference
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