lipid nanoparticle, lipid nanoparticles, Lipid NP, LNP, LNP preparation, LNP formulation, lipid nanoparticle synthesis, liposome, mRNA encapsulation, precigenome, mRNA LNP, PLGA, drug delivery, precision medicine, nanogenerator, flex-s, flex-m, pro, max, precisionnanosystems, pni, NanoAssemblr, ignite, spark

high throughput screening, small volume LNP synthesis, automated LNP preparation, lipid nanoparticle, lipid nanoparticles, Lipid NP, LNP, LNP preparation, LNP formulation, lipid nanoparticle synthesis, liposome, mRNA encapsulation, precigenome, mRNA LNP, PLGA, drug delivery, precision medicine, nanogenerator, flex-s, flex-m, pro, max, precisionnanosystems, pni, NanoAssemblr, ignite, spark

NanoGenerator® Flex-S Plus Platform
Automated High-throughput
Discovery & Screening
for Lipid Nanoparticle Formulation

High throughput 96 samples per hour
Small volume output

The NanoGenerator Flex-S Plus is an automated high-throughput formulation screening platform designed for nanoparticle synthesis, including lipid nanoparticles (LNPs), liposomes, etc.

Notably, the rapid adoption of LNP technology has underscored the potential of nanomedicines. Scientific advancements have demonstrated that LNPs serve as highly effective drug delivery systems across various therapeutic applications. High-throughput LNP screening is a valuable method for identifying the optimal LNP formulations from a diverse set of factors.

The NanoGenerator Flex-S Plus streamlines the process, enabling a swift transition from screening nano-formulations to clinical evaluation and ultimately commercialization. NanoGenerator produces nanoparticles with improved size uniformity and a lower polydispersity index (PDI). It offers scalable production, ranging from ultra-low volumes of 0.1 mL for early-stage screening to large-scale batch production of hundreds of liters, enabling seamless, continuous GMP-compliant manufacturing.

System Benefits

Automation

Automated workflow
Real-time data monitoring & recording
Electronic batch records

High Throughput & Efficiency

Multiple samples (up to 48) per run
Runtime <5min for 4 samples, 96 samples per hour
Scalable and reproducible to large volume production

High Yield

Small reagent volume (minimum 100ul) per sample
Save up to 80% of RNA/lipid cost

The NanoGenerator S plus revolutionizes lipid nanoparticle processing by offering a fully automated workflow designed to streamline research and development. This innovative platform integrates key processes, including automated lipid mix preparation, lipid nanoparticle synthesis, and downstream buffer exchange, into a single cohesive system. By combining these essential steps, the NanoGenerator provides researchers with an efficient, high-throughput screening solution that simplifies complex workflows and enhances productivity.

s plus automated workflow, system specs of flex s and s plus, high throughput screening, small volume LNP synthesis, automated LNP preparation, lipid nanoparticle, lipid nanoparticles, Lipid NP, LNP, LNP preparation, LNP formulation, lipid nanoparticle synthesis, liposome, mRNA encapsulation, precigenome, mRNA LNP, PLGA, drug delivery, precision medicine, nanogenerator, flex-s, flex-m, pro, max, precisionnanosystems, pni, NanoAssemblr, ignite, spark

Its all-in-one design ensures consistency and precision, enabling scientists to focus on advancing their research while reducing manual intervention. With its cutting-edge technology, the NanoGenerator empowers researchers to accelerate the development of lipid nanoparticles for various applications, from drug delivery to gene therapy.

Reproducible
Discovery & Screening

PreciGenome's NanoGenerator platform's precise control of parameters ensures consistent critical quality attributes, such as particle size, throughout the entire development and manufacturing process. This guarantees speed, cost-effectiveness, and reliability at every stage.

flex s plus consiitancy for LNP thesis screening

Multi-sample Formulation Screening Example

LNP screening 32sample by S plus, flex s plus consiitancy for LNP thesis screening

32 sample screening (formulation & N:P ratio screening)

Screening factors with the Flex-S Plus include payloads, carrier formulation, total flow rate, flow rate ratio, N:P ratio, Lipid concentration, and payload concentration. Precise control of parameters ensures consistent CQAs, guaranteeing speed, cost-effectiveness, and reliability at every stage of the experiment.

Path from Discovery to Commercialization

NanoGenerator system offers controllable and reproducible mixing conditions, ensuring the accurate synthesis of LNPs through its scalable architecture found in the entire NanoGenerator product line. This architecture facilitates the seamless transfer of crucial process parameters, guaranteeing consistent critical quality attributes (CQAs) as one transitions from discovery and screening, process development to GMP production and commercial manufacturing for a wide range of applications, such as mRNA LNP vaccine development.

scalable results by NanoGenerotor LNP synthsis, high throughput screening, small volume LNP synthesis, automated LNP preparation, lipid nanoparticle, lipid nanoparticles, Lipid NP, LNP, LNP preparation, LNP formulation, lipid nanoparticle synthesis, liposome, mRNA encapsulation, precigenome, mRNA LNP, PLGA, drug delivery, precision medicine, nanogenerator, flex-s, flex-m, pro, max, precisionnanosystems, pni, NanoAssemblr, ignite, spark

Transferable results from early discovery and screening (Flex-S/Flex-S Plus, 0.1mL) to pre-clinical development (Flex-M and Flex-M Premium, 200mL), then commercial production (Max: 1L, MAX 40L/H: >20L)

Working Principle

Nanoparticle synthesis via microfluidic mixing has superior control of size, homogeneity, and repeatability to conventional batch synthesis methods. Two streams, aqueous and solvent, meet in a narrow mixing channel, forming nanoparticles with payload encapsulated.

Learn More

Workflow

system specs of flex s and s plus, high throughput screening, small volume LNP synthesis, automated LNP preparation, lipid nanoparticle, lipid nanoparticles, Lipid NP, LNP, LNP preparation, LNP formulation, lipid nanoparticle synthesis, liposome, mRNA encapsulation, precigenome, mRNA LNP, PLGA, drug delivery, precision medicine, nanogenerator, flex-s, flex-m, pro, max, precisionnanosystems, pni, NanoAssemblr, ignite, spark

The Flex-S Plus System facilitates the rapid screening of nanoparticle formulations and early-stage mRNA candidates, offering a substantial increase in project efficiency. With a max throughput of 48/96 experiments an hour, the Flex-S Plus greatly streamlines screening processes. It offers comprehensive automation of complex protocols, enabling users to concentrate on other laboratory duties.

Workflow

The system also permits experimentation with as little as 20 µl of payload reagent (e.g. mRNA) while providing control over collection volumes. This allows users to optimize the use of valuable materials.

Screening factors with the Flex-S Plus include payloads, carrier formulation, total flow rate, flow rate ratio, N:P ratio, and LNP concentration. Precise control of parameters ensures consistent CQAs, guaranteeing speed, cost-effectiveness, and reliability at every stage of the experiment.

Workflow for automated high throughput formulation